Surface modification of hydroxyapatite nanoparticles by poly(l-phenylalanine) via ROP of l-phenylalanine N-carboxyanhydride (Pha-NCA)

► The surface of hydroxyapatite nanoparticles were modified by poly(l-phenylalanine)(PPha) via the ring opening polymerization method. ► PPha chains on the surface of HA could main its colloid stability in organic solvent and prevent the aggregation of HA nanoparticles. ► The biocompatibility of PPha modified HA was good, demonstrating its potential application in bone tissue engineering.