کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5367402 | 1388365 | 2011 | 8 صفحه PDF | دانلود رایگان |
In order to improve the dissolution rate and increase the bioavailability of a poorly water-soluble drug, intended to be administered orally, the biocompatible and bioactive mesoporous hydroxyapatite (HA) was successfully synthesized. In the present study, mesoporous HA nanoparticles were produced using Pluronic block co-polymer F127 and cetyltrimethylammonium bromide (CTAB) as templates by the hydrothermal method. The obtained mesoporous HA was employed as a drug delivery carrier to investigate the drug storage/release properties using carvedilol (CAR) as a model drug. Characterizations of the raw CAR powder, mesoporous HA and CAR-loaded HA were carried out by the scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy, N2 adsorption/desorption, thermogravimetric analysis (TGA), and UV-VIS spectrophotometry. The results demonstrated that CAR was successfully incorporated into the mesoporous HA host. In vitro drug release studies showed that mesoporous HA had a high drug load efficiency and provided immediate release of CAR compared with micronized raw drug in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 6.8). Consequently, mesoporous HA is a good candidate as a drug carrier for the oral delivery of poorly water-soluble drugs.
Highlights⺠Mesoporous hydroxyapatite was synthesized using F127 and CTAB as templates. ⺠Carvedilol was selected as a model drug. ⺠Carvedilol in an amorphous state was incorporated in mesoporous hydroxyapatite. ⺠Hydroxyapatite had a high drug load efficiency and provided fast release of carvedilol. ⺠Hydroxyapatite is a good carrier for the oral delivery of poorly water-soluble drugs.
Journal: Applied Surface Science - Volume 257, Issue 23, 15 September 2011, Pages 10126-10133