کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5375785 | 1504304 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of the substituent on amide nitrogen atom of N-acetyl tyrosine on interactions with β-cyclodextrin
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The influence of substituent on amide nitrogen atom on the interactions of N-acetyl tyrosine amides with β-cyclodextrin was studied by means of steady-state and time-resolved fluorescence spectroscopy, 2D 1H NMR, and microcalorimetry. In comparison with AcTyr-OH a primary amide group only in a small degree modified the binding constant with β-CD, regardless of the structure (linear or branched) and the length of n-alkyl substituent which for primary amides (methyl, ethyl, n-propyl, iso-propyl, n-butyl, and sec-butyl), as determined from the microcalorimetric titrations, is in the range from 122 Mâ1 to 190 Mâ1, except for t-butyl substituent for which the highest binding constant (over 500 Mâ1) was determined. Moreover, for a branched substituent binding constants are a little higher in comparison with n-alkyl ones. For secondary amides (di-methyl, di-ethyl, di-n-propyl, di-iso-propyl, and di-iso-butyl) the binding constants are higher (in the range from 270 Mâ1 to 410 Mâ1).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Physics - Volume 354, Issues 1â3, 10 December 2008, Pages 58-70
Journal: Chemical Physics - Volume 354, Issues 1â3, 10 December 2008, Pages 58-70
نویسندگان
Justyna Mrozek, Bogdan Banecki, Emilia Sikorska, Agnieszka Skwierawska, Jerzy Karolczak, WiesÅaw Wiczk,