Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution

The ionic repulsion of a 13C-enriched magnetic resonance chemical probe with a Gd complex, doped as an enhancer of preceding solid-state polarization build-up, prevented the T1 shortening effect by paramagnetic Gd ions in the liquid-state after dissolution. Meanwhile, the ionic attraction between a probe and a complex allowed the Gd ions in close proximity to the 13C nuclei and drastically shortened the hyperpolarized 13C lifetime.57