کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5424903 | 1395841 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A high throughput approach to quantify protein adsorption on combinatorial metal/metal oxide surfaces using electron microprobe and spectroscopic ellipsometry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although metallic biomaterials are widely used, systematic studies of protein adsorption onto such materials are generally lacking. Combinatorial binary films of Al1âxTix and Al1âxNbx (0 ⩽ x ⩽ 1) and corresponding pure element films were produced on glass substrates using a unique magnetron sputtering technique. Fibrinogen and albumin adsorption amounts were measured by wavelength-dispersive spectroscopy (WDS) and spectroscopic ellipsometry (SE) equipment, both high throughput techniques with automated motion stage capabilities. X-ray diffraction revealed that the binary films have crystalline phases present near the ends of the compositional gradient with an amorphous region throughout the interior of the gradient. X-ray photoelectron spectroscopy provided the surface chemistry along the binary films and showed that Al2O3 preferentially formed at the surface. Protein adsorption onto these films was found to be closely correlated to the alumina surface fraction, with high alumina content at the surface leading to low amounts of adsorbed fibrinogen and albumin. Protein adsorption amounts obtained with WDS and SE were in excellent agreement for all films. This suggests that this combinatorial materials approach combined with these state-of-the-art, automated high throughput instruments provides a novel way to accurately monitor protein adsorption taking place at the surfaces of these metal/metal oxide materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surface Science - Volume 602, Issue 17, 1 September 2008, Pages 2927-2935
Journal: Surface Science - Volume 602, Issue 17, 1 September 2008, Pages 2927-2935
نویسندگان
T. Byrne, L. Lohstreter, M.J. Filiaggi, Zhijun Bai, J.R. Dahn,