کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5434241 | 1509140 | 2017 | 7 صفحه PDF | دانلود رایگان |
- The graphene oxide was wrapped in the outer layer of the short fibers.
- Fe3O4were nanoparticles encapsulated in the short fibers.
- High magnetic response of short fibers compared to results reported before.
- Phenomenon that cells tightly bound to the fibers was observed.
- Feasibility that the formation of cell aggregates promoted by magnetic short fibers was proved.
Magnetic particles show extremely wide application prospects in the biomedical field, particularly in the success of cellular manipulation, drug delivery systems, magnetic hyperthermia and NRI contrast enhancement. Graphene oxide with functional groups has a promising biological effect. In this work, we develop magnetic short-fibers wrapped graphene oxide for guiding cellular behavior with the aid of high-speed shear of nanofibers fabricated through electrospinning technique. The diameter and the length of short-fibers are about 300 nm and 80 μm, respectively. The short-fibers exhibit superior magnetic properties (saturation magnetization value: 50.33 emu/g), which has a strong response appearance to the NdFeB magnet. SEM images and laser confocal images display that there has an extremely tight adhesion between the short-fibers wrapped graphene oxide and cells. The control of cell-fibers structure behavior can be realized by applying external magnet. The results may provide an attractive perspective on the treatment of disease with magnetic field.
Journal: Materials Science and Engineering: C - Volume 81, 1 December 2017, Pages 314-320