Polymeric nanoparticles: A study on the preparation variables and characterization methods

- Toolbox of available methods for the preparation of polymeric nanoparticles
- Effects of formulation variables and characterization methods of polymeric nanoparticles
- Preparation of well-defined polymeric nanoparticles

Since the emergence of Nanotechnology in the past decades, the development and design of nanomaterials has become an important field of research. An emerging component in this field is nanomedicine, wherein nanoscale materials are being developed for use as imaging agents or for drug delivery applications. Much work is currently focused in the preparation of well-defined nanomaterials in terms of size and shape. These factors play a significantly role in the nanomaterial behavior in vivo. In this context, this review focuses on the toolbox of available methods for the preparation of polymeric nanoparticles. We highlight some recent examples from the literature that demonstrate the influence of the preparation method on the physicochemical characteristics of the nanoparticles. Additionally, in the second part, the characterization methods for this type of nanoparticles are discussed.

Nanomedicine's Fantastic Voyage through the use of nanoscale materials has witnessed unprecedented growth of research and applications. Polymeric nanoparticles have been widely used for controlled drug delivery as vehicles for therapeutics. Much work is currently focused in the preparation of well-defined nanomaterials as these factors play a significantly role in their behavior in vivo. A toolbox of available methods for the preparation and characterization of polymeric nanoparticles is presented.261