A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis

- Green synthesis of platinum nanoparticles using Chondroitin sulfate
- Stabilization of PtNPs with oxidized Chondroitin sulfate
- Dose dependent cytotoxicity of PtNPs against Osteoarthritis chondrocytes

The present work showed the biofabrication of platinum nanoparticles (PtNPs) using chondroitin sulfate via a facile, eco-friendly route by just heating leaf extract and H2PtCl6·6H2O (Chloroplatinic acid) solution which gave a brown-colored PtNPs dispersion. The assynthesized PtNPs were analyzed by using Transmission electron microscopy (TEM), Energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Selected area electron diffraction (SAED). TEM analysis showed PtNPs of irregular shape with a size existed in the range from 3 to 5 nm. From zeta potential studies it is found the surface charge of the synthesized PtNPs is negative (− 25.6 mV). FTIR analysis and zeta potential measurements of PtNPs confirm the capping of chondroitin sulfate onto the surface of nanoparticles. XRD and SAED pattern revealed the crystalline nature of synthesized nanoparticles. Further, the in-vitro cytotoxicity of PtNPs against the osteoarthritis chondrocytes showed their biocompatibility, hence the obtained nanoparticles may have future scope in the treatment of osteoarthritis. Also, the present approach is green alternative to the traditionally available chemical methods that are currently been used now a days using chemical reagents such that are hazardous to human and environment.

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