Fabrication of vinyl organosilicon @poly-N, N′-[(4, 5-dihydroxy-1, 2-phenylene)bis(methylene)]bisacrylamide) core@shell antibacterial agent

- Vinyl organosilicon cores were facilely fabricated by sol-gel method.
- Core-shell antibacterial structure was assembled by polymerization reaction.
- Core-shell structure displayed high antibacterial performance.
- Their long-term stability and broad-spectrum antibacterial effect were confirmed.

We demonstrate that antibacterial agent N, N′-[(4, 5-dihydroxy-1, 2-phenylene)bis(methylene)]bisacrylamide (OHABA) can be assembled on the surface of vinyl organosilicon nanospheres (VOSNs) by atom transfer radical polymerization (ATRP). Chemically cross-linked vinyl organosilicon cores were facilely fabricated by sol-gel method as support, which densely grafted poly-OHABA (POHABA) as shells. Antibacterial assessment test results revealed that POHABA-based core@shell structure displayed high antibacterial performance, long-term stability, and kept broad-spectrum antibacterial effect of against Gram-negative and Gram-positive bacteria.