کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5434848 | 1509146 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Salecan is a new water-soluble microbial polysaccharide.
- Salecan-containing semi-IPN hydrogels were synthesized.
- Effect of Salecan content on the properties of the hydrogels were studied.
- The Salecan-based hydrogel was an effective vehicle for drug encapsulation/release.
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.
Journal: Materials Science and Engineering: C - Volume 75, 1 June 2017, Pages 487-494