کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434852 1509146 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation on Au-nano incorporated pH-sensitive (itaconic acid/acrylic acid/triethylene glycol) based polymeric biocompatible hydrogels
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Investigation on Au-nano incorporated pH-sensitive (itaconic acid/acrylic acid/triethylene glycol) based polymeric biocompatible hydrogels
چکیده انگلیسی


- Itaconic acid based hydrogels were developed viz. greener organic solvent less approach.
- The enhanced equilibrium swelling at acidic and basic medium was observed for nano-Au-incorporated nano composite hydrogels.
- The prepared GIAT hydrogel showed ~ 99% of cell proliferation.
- This kind of pH-sensitive polymeric hydrogels may be useful for controlled drug delivery system.

The pH-sensitive gold nano hydrogel based on itaconic acid, acrylic acid and triethylene glycol (GIAT) has been prepared by free radical polymerization viz. organic solventless approach with different monomer ratios. The nature of bonding and structural identification of GIAT hydrogels were characterized by FT-IR spectroscopy. The surface morphology of gold gel was examined using scanning electron microscopy (SEM). In addition, transmission electron microscopy (TEM) was used to identify the size of gold nano particles. The in vitro biocompatibility of GIAT hydrogel has been evaluated in 3T3 fibroblast cell lines. The obtained results show that gold nano particle incorporated hydrogel possess ~ 99% of cell proliferation. Followed by, the impact of gold nano particles on swelling, surface morphology was studied. The consecutive preparation of hydrogel, effect of different pH conditions, and stoichiometry of monomeric units have also been discussed. The degree of swelling was measured in carbonate buffer solutions for 24 h period with varying pH such as 1.2, 6.0, 7.4 and 10.0. The obtained results showed that the stoichiometry of itaconic acid and gold nano particles plays an essential role in modifying the nature of GIAT polymeric hydrogels. In conclusion, promising Au-nano incorporated pH-sensitive bio polymeric hydrogels were prepared and characterized. The unique properties of these Au-nano hydrogel make them attractive use in biomedical applications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 75, 1 June 2017, Pages 517-523
نویسندگان
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