Simultaneous voltammetric analysis of anti-ulcer and D2-antagonist agents in binary mixture using redox sensor and their determination in human serum

- Voltammetric analysis of pantoprazole sodium and domperidone for the first time.
- Poly (EBT)/PGE was used.
- Investigation of the electro-deposition polymer using FTIR and SEM images.
- High sensitivity and selectivity of the proposed method.
- Application of the new sensor for determination of the binary mixture in synthetic mixtures and human serum.

Pencil graphite electrode was successfully modified with a thin film of poly (eriochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of pantoprazole sodium and domperidone in a binary mixture. The preparation and basic electrochemical behavior of poly (eriochrome black T) film on the Pencil graphite electrode were investigated. The modified electrode has exhibited very high electro-catalytic activity towards the cited mixture. The anodic peaks of the both species were well defined with enhanced oxidation peak currents. Under the optimum conditions, the linearity ranges were 0.4-55 × 10− 7 M and 0.1-34 × 10− 7 M for pantoprazole sodium and domperidone, respectively with detection limits of 0.12 × 10− 7 M and 0.04 × 10− 7 M for pantoprazole sodium and domperidone, respectively. The proposed sensor has been successfully applied in the analysis of pantoprazole sodium and domperidone in synthetic binary mixtures and human serum.

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