A sensitive voltammetric detection of pramipexole based on 1,1,3,3-tetramethyldisilazanecarbon nanotube modified electrode

- The MWCNT was functionalized with TMDS molecule by a simple and low-cost method.
- The new nanostructure sensor based on glassy carbon electrode modified with TMDS-MWCNT
- It was found that TMDS-MWCNT/GCE exhibits good catalytic activity toward the oxidation of pramipexole.
- This sensor showed concentration range of 0.8 to 600 μM with a detection limit of 0.2 μM.
- The proposed method does not differ significantly in precision and accuracy from the reference method.

A simple low-cost method is proposed to fabricate a functionalized multi-wall carbon nanotube (MWCNT) with 1,1,3,3-tetramethyldisilazane (TMDS) molecule. The techniques of scanning electron microscope (SEM) with electron diffraction and energy dispersive X-ray (EDAX) analysis were applied to characterize the functionalized TMDS-MWCNT. The results showed that a MWCNT with high functionalization of TMDS can be obtained using this simple method. A new nanostructure sensor was constructed based on a glassy carbon electrode modified with TMDS-MWCNT (TMDS-MWCNT/GCE). It was found that the TMDS-MWCNT/GCE exhibits good catalytic activity toward oxidation of pramipexole (PPX) drug, leading to a concentration range of 0.8 to 600 μM with a detection limit of 0.2 μM at 3σ using the differential pulse voltammetry technique, a sensitivity of 0.084 μA μM− 1, and a correlation coefficient of 0.991. Furthermore, the TMDS-MWCNT/GCE was used for PPX detection in tablets and human blood serum samples. The method showed no interference from tablet excipients; hence, it can be useful and fit for the quantification of PPX in bulk and tablet dosage forms. The proposed method was validated successfully as applied to the quantification of the drug in tablet dosage forms. The accuracy of detection results using the proposed method was evaluated as excellent comparing with those obtained by the reference method.

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