MoS2/reduced graphene oxide nanocomposite for sensitive sensing of cysteamine in presence of uric acid in human plasma

- The hybrid nanocomposite composed of MoS2 nanosheets and reduced graphene oxide was fabricated by a facile and effective method.
- The MoS2 nanosheets were uniformly anchored on the rGO framework with strong adhesion.
- Glassy carbon electrodes modified with MoS2-rGO was used for electro-oxidation of cysteamine (CA) in presence of uric acid (UA).
- The anodic peak current of CA at the surface of modified electrode is linear to its concentration ranges at 0.01 to 20 μM with a detection limit of 7 nM.
- The proposed electrochemical sensor was used for determination of CA in human plasma.
- The accuracy of the method was as excellent comparing with the obtained results using reference method.

A hybrid nanocomposite of MoS2 nanosheets and reduced graphene oxide (rGO) was fabricated by a facile and effective method. The morphology and structure of the nanocomposite (MoS2-rGO) were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, electrochemical impedance spectroscopy and cyclic voltammetry. The MoS2 nanosheets were uniformly anchored on the rGO framework with strong adhesion. A glassy carbon electrode modified by drop-casting with MoS2-rGO was used for the electrochemical oxidation of cysteamine (CA) in the presence of uric acid (UA). Under optimum conditions, the anodic peak current of CA shows a linear relation with the CA concentration between 0.01 and 20 μM with a detection limit of 7 nM. The proposed electrochemical sensor was used for determination of CA in human plasma.