کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5435051 | 1509147 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On spray drying of oxidized corn starch cross-linked gelatin microcapsules for drug release
ترجمه فارسی عنوان
در خشک کردن اسپری نشاسته اکسید شده از میکروکپسول های ژلاتین متقاطع برای انتشار مواد مخدر
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کلمات کلیدی
ژلاتین، نشاسته ذرت اکسید شده، میکرو کپسول،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Spray-dried gelatin/oxidized corn starch (G/OCS) microcapsules were produced for drug release application. The prepared microcapsules were characterized through a scanning electron microscope (SEM) picture and thermogravimetric analysis (TGA). The swelling characteristics of the G/OCS microcapsules and release properties of vitamin C were then investigated. The results from structural analysis indicated that the presence of miscibility and compatibility between oxidized corn starch and gelatin, and exhibits high thermal stability up to 326 °C. The swelling of G/OCS microcapsules increased with increasing pH and reduced with decreasing ionic strength, attributed to the cross-linking between gelatin and oxidized corn starch, ionization of functional groups. Vitamin C release characteristic revealed controlled release behavior in the first 3 h of contact with an aqueous medium. This release behavior was independent of the swelling behavior indicating the potential of the encapsulating matrix to produce controlled release across a spectrum of pH environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 74, 1 May 2017, Pages 493-500
Journal: Materials Science and Engineering: C - Volume 74, 1 May 2017, Pages 493-500
نویسندگان
Xugang Dang, Mao Yang, Zhihua Shan, Shahnaz Mansouri, Bee K May, Xiaodong Chen, Hui Chen, Meng Wai Woo,