The effects of titanium dioxide nanoparticles on ultrastructure of zebrafish testis (Danio rerio)

TiO2-NP has been used in crop production, food additives, medicine, toothpastes, sunscreens, cosmetics, and in waste water treatment, which contaminated the environment. Our findings showed TiO2-NP-induced autophagy and necrosis at higher doses in Sertoli cells, which consequently negatively affected spermatogenic cells and testicular morphology of Zebrafish. It is important to give much more attention to the use of this NP to minimise the possible effects on nature and organisms.