کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5463616 | 1517199 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In situ delivery of rhBMP-2 in surface porous shape memory scaffolds developed through cryogenic 3D plotting
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In situ delivery of rhBMP-2 in surface porous shape memory scaffolds developed through cryogenic 3D plotting In situ delivery of rhBMP-2 in surface porous shape memory scaffolds developed through cryogenic 3D plotting](/preview/png/5463616.png)
چکیده انگلیسی
Three dimension (3D) printing has been increasingly used to make tissue engineering scaffolds. However, polyester-based scaffolds made through traditional 3D printing such as fused deposition modeling (FDM) lack of bioactivity as biomolecules cannot be directly blended with inks to achieve an in situ delivery. In addition, with increasing demand of reducing surgical trauma, implanting scaffolds through a minimally invasive way is of great importance. Here, surface porous tissue engineering scaffolds were made from novel poly(D,L-lactic acid-co-trimethylene carbonate)-based water-in-oil emulsions through a cryogenic 3D plotting. The effects of water content in emulsions on the microstructure of 3D plotted scaffolds were investigated. With heat treatment at 40 °C, scaffolds became soft and can be injected into a catheter. Growth factors can be loaded into the scaffolds in situ and showed a sustained release within 30 days.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 189, 15 February 2017, Pages 140-143
Journal: Materials Letters - Volume 189, 15 February 2017, Pages 140-143
نویسندگان
Chong Wang, Yu Zhou, Min Wang,