Tunable pore sizes of monodispersed amorphous calcium phosphate hollow nanospheres

In this paper, tunable pore sizes of monodispersed amorphous calcium phosphate (ACP) hollow nanospheres are prepared, and the effects of shell's pore sizes on the loading capacity are investigated. Results show that the shell's pore sizes can be tuned from 3 nm to 50 nm by controlling the coating time. Adsorption results show that the loading capacity of hollow spherical ACP increases with the increasing of pore sizes. When the pore sizes are around 8-25 nm, the large molecular doxorubicin hydrochloride (DOX·HCl) can enter the hollow spheres freely, and the loading capacity reaches the largest 1181.9 mg/g. When the pore sizes are bigger than 25 nm, the specific surface areas decrease greatly, which resulted in the loading capacities decreasing.