Preparation and properties of poly(lactic acid) melt spun fiber aligned and disordered scaffolds

Aligned structure of extracellular matrix (ECM) plays a positive role in the surrounding environment and phenotype, it's necessary to simulate aligned structure of tissue and natural cell environment by aligned scaffolds. In this paper, aligned and disordered scaffolds were prepared by poly(lactic acid) (PLA) melt spun fiber and polyurethane (PU) adhesive. It can be found that PLA melt spun fiber aligned scaffold has smaller thickness, weight, pore diameter, porosity and strain while larger alignment degree and stress than disordered scaffold. This research provides a new method to prepare PLA melt spun fiber aligned scaffold could be potentially used to simulate ECM in tissue engineering.