Facile synthesis of hollow bioactive glass nanospheres with tunable size

- Sol-gel synthesis of HBG nanospheres though PAA template.
- Synthesis of hollow bioactive glass nanospheres with tunable size.
- HBG nanospheres with good bioactivity can be used as an innovative platform to delivery bioactive drugs.

Hollow nanospherical bioactive glasses were conducted though sol-gel process using poly(acrylic acid) (PAA) as the template. The incorporation of PAA was to form the core after air combustion, whereas the inorganic shell was produced by glass precursor. The mixture of different tetraorthosilicate (TEOS)/PAA contents into a glass network tailored the shell thickness, morphological, and structural properties of HBGs. The in vitro bioactivity evaluation confirmed that HBG2 sample exhibited good apatite formation ability, thereby denoting that the proposed method enhanced the potential application of HBGs in bone tissue regeneration and drug delivery.

One-step synthesis of hollow bioactive glass with tunable size by using PAA templates.160