Insulin overlapping in whole blood FTIR spectroscopy in blood glucose measurements

For the last decade, several studies on mid-IR spectroscopy for blood glucose quantification have not considered the compounds involved in the glucose regulation mechanism, in which insulin plays an important role. This work shows how insulin overlaps in the same mid-IR region in which glucose is quantified. This optical absorption interference is an important factor to be considered for this type of studies, in the scope of whole blood modeling for spectroscopy applications and the possible use of computer based metrics.