کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5498006 | 1532076 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formulation and purification of therapeutic dose of 90Y-labeled peptides: Some interesting radiochemistry aspects
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Formulation and purification of therapeutic dose of 90Y-labeled peptides: Some interesting radiochemistry aspects Formulation and purification of therapeutic dose of 90Y-labeled peptides: Some interesting radiochemistry aspects](/preview/png/5498006.png)
چکیده انگلیسی
Yttrium-90 obtained from most of the 90Sr/90Y generators contains 90Sr impurity above permissible limit for human administration. A protocol has been optimized for formulation of therapeutic dose of 90Y-DOTA-Tyr3-octreotate (90Y-DOTA-TATE) and removal of 90Sr impurity from it. The radiochemical purity of 90Y-DOTA-TATE was found to be >98% and it met the requirements for clinical use. The radiopharmaceutical was used in preliminary clinical investigation in patients with neuroendocrine tumors. This promising strategy would aid toward widespread clinical utilization of 90Sr/90Y generators.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 121, March 2017, Pages 1-5
Journal: Applied Radiation and Isotopes - Volume 121, March 2017, Pages 1-5
نویسندگان
Rubel Chakravarty, Sudipta Chakraborty, Ashutosh Dash,