کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5500574 | 1534293 | 2017 | 80 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
ترجمه فارسی عنوان
مرتبط با سلامت تغییر التهاب با درجه پایین در پیری (التهاب) و نقش تغذیه
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کلمات کلیدی
مغز، خلط، چربی چاقی، انحطاط، سیتوکین، میکروبیوتا، پروبیوتیک پرای بیوتیک، آنتی اکسیدان، امگا 3، سالخورده، مسن، التهاب التهاب التهاب بهداشت و سلامت،
Antioxidant - آنتی اکسیدانInflammaging - التهابinflammation - التهاب( توروم) Omega-3 - امگا 3Degeneration - انحطاطHealth and wellbeing - بهداشت و سلامتیAgeing - سالخوردهElderly - سالمندیCytokine - سیتوکینObesity - مرض چاقیBrain - مغزMicrobiota - میکروبیوتاProbiotic - پروبیوتیکprebiotic - پروبیوتیکAdipose - چربیGut - گل سرخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Ageing of the global population has become a public health concern with an important socio-economic dimension. Ageing is characterized by an increase in the concentration of inflammatory markers in the bloodstream, a phenomenon that has been termed “inflammageing”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low grade inflammation is likely to be detrimental for many tissues and for normal functions. We provide an overview of low grade inflammation (LGI) and determine the potential drivers and the effects of the “inflamed” phenotype observed in the elderly. We discuss the role of gut microbiota and immune system crosstalk and the gut-brain axis. Then, we focus on major health complications associated with LGI in the elderly, including mental health and wellbeing, metabolic abnormalities and infections. Finally, we discuss the possibility of manipulating LGI in the elderly by nutritional interventions. We provide an overview of the evidence that exists in the elderly for omega-3 fatty acid, probiotic, prebiotic, antioxidant and polyphenol interventions as a means to influence LGI. We conclude that slowing, controlling or reversing LGI is likely to be an important way to prevent, or reduce the severity of, age-related functional decline and the onset of conditions affecting health and well-being; that there is evidence to support specific dietary interventions as a strategy to control LGI; and that a continued research focus on this field is warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 40, November 2017, Pages 95-119
Journal: Ageing Research Reviews - Volume 40, November 2017, Pages 95-119
نویسندگان
Philip C. Calder, Nabil Bosco, Raphaëlle Bourdet-Sicard, Lucile Capuron, Nathalie Delzenne, Joel Doré, Claudio Franceschi, Markus J. Lehtinen, Tobias Recker, Stefano Salvioli, Francesco Visioli,