TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity

Fig: The picture depicts the hepatocyte- Kupffer cells crosstalk and mechanism of TRPV4 activation. The activated TRPV4 induces Nitric oxide release in kupffer cells and further inhibition of CYP2E1 activity in hepatocytes.196