کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5511658 | 1540214 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of an innate immune response by soluble yeast β-glucan prepared by a heat degradation method
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
β-glucan is widely distributed in nature as water soluble and insoluble forms. Both forms of β-glucan are applied in several fields, especially for functional foods. Yeast β-glucan is a medically important insoluble particle. Solubilization of yeast β-glucan may be a valuable approach to increase functional foods and medicinal fields. We have applied a heat degradation method to solubilize yeast β-glucan and found that it was effectively solubilized by treatment with an aqueous suspension at 135 °C for several hours. The solubilized yeast β-glucan (hd-sBBG) exhibited antagonistic activity to the reactive oxygen production of macrophages and to the cytokine synthesis of macrophages. hd-sBBG strongly reacted with the anti-β-glucan antibody in human sera and with dectin-1, the innate immune receptor of β-glucan. From these findings, the heat degradation method is an important procedure for making immune modulating soluble yeast β-glucan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 104, Part A, November 2017, Pages 367-376
Journal: International Journal of Biological Macromolecules - Volume 104, Part A, November 2017, Pages 367-376
نویسندگان
Yuina Ishimoto, Ken-ichi Ishibashi, Daisuke Yamanaka, Yoshiyuki Adachi, Ken Kanzaki, Kumiko Okita, Yoichiro Iwakura, Naohito Ohno,