کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5511926 | 1540217 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural characters and protecting β-cells of a polysaccharide from flowers of Inula japonica
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural characters and protecting β-cells of a polysaccharide from flowers of Inula japonica Structural characters and protecting β-cells of a polysaccharide from flowers of Inula japonica](/preview/png/5511926.png)
چکیده انگلیسی
Our previous studies found that the crude polysaccharides (IJP) from flowers of Inula japonica exhibited significantly anti-diabetic activity in alloxan or MLD-STZ induced diabetic mice. In this study, we will trace an active polysaccharide from IJP and investigate its physico-chemical property and its protective mechanism on islet cell damage. The result showed that an active polysaccharide (IJP-B-1) was isolated from IJP, its molecular mass was 3.7 Ã 104 Da. IJP-B-1 was composed of rhamnose, arabinose, xylose, mannose, glucose, galactose and galactocuronic acid. Its major backbone structure was (1 â 3, 6)-linked-galactose and other branched residues. IJP-B-1 could protect pancreatic cells against STZ impairment at 50 μg/mL and scavenge OH and O2 radicals to decrease reactive oxygen generation in islet-cells in vitro. These results suggested that IJP-B-1 might be useful for protecting β-cells and against oxidative stress as an anti-diabetic candidate drug in future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 101, August 2017, Pages 16-23
Journal: International Journal of Biological Macromolecules - Volume 101, August 2017, Pages 16-23
نویسندگان
Chunzhi Zhao, Yulin Diao, Changzhen Wang, Wensheng Qu, Xiunan Zhao, Hao Ma, Junjie Shan, Guohui Sun,