کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5511935 1540217 2017 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic effect of divalent cations in improving technological properties of cross-linked alginate beads
ترجمه فارسی عنوان
اثر هم افزایی کاتدی دوالنت در بهبود خواص فن آوری دانه های آلژینات متقاطع
کلمات کلیدی
کاتیون گلی اثر سینرژیک، ژلاتین یوناتروپیک، دانه های آلژینات، انتشار کنترل شده،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Gelling solution parameters are some of the most important variables in ionotropic gelation and consequently influence the technological characteristics of the product. To date, only a few studies have focused on the simultaneous use of multiple cations as gelling agents. With the aim to deeply explore this possibility, in this research we investigated the effect of two divalent cations (Ca2+ and Zn2+) on alginate beads formation and properties. Alginate beads containing prednisolone (P) as model drug were prepared by prilling technique. The main critical variables of the ionotropic gelation process i.e. composition of the aqueous feed solutions (sodium alginate and prednisolone concentration) and cross-linking conditions (Ca2+, Zn2+ or Ca2+ + Zn2+), were studied. The obtained beads were characterized and their in vitro release performances were assessed in conditions simulating the gastrointestinal environment. Results evidenced a synergistic effect of the two cations, affecting positively both the encapsulation efficiency and the ability of the alginate polymeric matrix to control the drug release. A Ca2+/Zn2+ ratio of 4:1, in fact, exploited the Ca2+ ability of establish quicker electrostatic interactions with guluronic groups of alginate and the Zn2+ ability to establish covalent-like bonds with carboxylate groups of both guluronic and mannuronic moieties of alginate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 101, August 2017, Pages 100-106
نویسندگان
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