کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5512437 1540223 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Designing chitosan-tripolyphosphate microparticles with desired size for specific pharmaceutical or forensic applications
ترجمه فارسی عنوان
طراحی میکروپارسیت های کیتوزان-تربلی پلی فسفات با اندازه مورد نظر برای کاربرد داروهای خاص یا پزشکی قانونی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Chitosan (CS) is a natural cationic polymer obtained by the partial N-deacetylation of chitin. Chitosan microparticles can be prepared by cross-linking with tripolyphosphate (TPP) via the ionic interaction between positively charged amino groups (CS) and negatively charged counter ions (TPP). This can be controlled by the charge density of CS and TPP, which depend on the pH and ionic strength of the solution. The purpose of this study is to investigate the combined effects of three independent variables (pH, ionic strength and CS:TPP ratio) on three important physico-chemical properties (viscosity, zeta potential and particle size) during the preparation of microparticles. CS:TPP microparticles were prepared using experimental design and equations were generated and used to predict relative viscosity, zeta potential and particle size under different conditions. This gives us the ability to design tuneable CS-TPP microparticles with desired size for specific pharmaceutical or forensic applications e.g. latent fingerprint visualisation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 95, February 2017, Pages 564-573
نویسندگان
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