کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5512619 | 1540221 | 2017 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dihedral angle preferences of DNA and RNA binding amino acid residues in proteins
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dihedral angle preferences of DNA and RNA binding amino acid residues in proteins Dihedral angle preferences of DNA and RNA binding amino acid residues in proteins](/preview/png/5512619.png)
چکیده انگلیسی
A protein can interact with DNA or RNA molecules to perform various cellular processes. Identifying or analyzing DNA/RNA binding site amino acid residues is important to understand molecular recognition process. It is quite possible to accurately model DNA/RNA binding amino acid residues in experimental protein-DNA/RNA complex by using the electron density map whereas, locating/modeling the binding site amino acid residues in the predicted three dimensional structures of DNA/RNA binding proteins is still a difficult task. Considering the above facts, in the present work, we have carried out a comprehensive analysis of dihedral angle preferences of DNA and RNA binding site amino acid residues by using a classical Ramachandran map. We have computed backbone dihedral angles of non-DNA/RNA binding residues and used as control dataset to make a comparative study. The dihedral angle preference of DNA and RNA binding site residues of twenty amino acid type is presented. Our analysis clearly revealed that the dihedral angles (Ï, Ï) of DNA/RNA binding amino acid residues prefer to occupy (â89° to â60°, â59° to â30°) bins. The results presented in this paper will help to model/locate DNA/RNA binding amino acid residues with better accuracy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 97, April 2017, Pages 434-439
Journal: International Journal of Biological Macromolecules - Volume 97, April 2017, Pages 434-439
نویسندگان
Karthe Ponnuraj, Konda Mani Saravanan,