کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5514759 | 1541692 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exercise modulates the aortic renin-angiotensin system independently of estrogen therapy in ovariectomized hypertensive rats
ترجمه فارسی عنوان
ورزش، سیستم رینین-آنژیوتانسین آئورت را مستقل از استروژن در موشهای مبتلا به هورمون انسدادی تخمدان
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کلمات کلیدی
NADPHOVXAT1NOSAT2ACEp22phoxANPmRNAKClGp91phoxAng-(1-7) - 1- (1-7)17β-estradiol - 17β استرادیولl-NAME - L-NAMEangiotensin converting enzyme - آنزیم تبدیل آنژیوتانسینAngiotensin (1-7) - آنژیوتانسین (1-7)Angiotensin II - آنژیوتانسین دوangiotensin type 1 receptor - آنژیوتانسین نوع 1 گیرندهACh - آهEstrogen Therapy - استروژن درمانAcetylcholine - استیل کولینOvariectomy - اوفورکتومی، تخمدان برداریMAS - بیشترcardiovascular disease - بیماری قلب و عروقیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceAng II - دومCVD - رسوب دهی شیمیایی بخار messenger ribonucleic acid - رسوب ریبونوکلئیک اسیدNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateatrial natriuretic peptide - پپتید نایروئیدوری دهلیزPotassium chloride - کلرید پتاسیمangiotensin type 2 receptor - گیرنده نوع 2 آنژیوتانسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The renin-angiotensin-system is an important component of cardiovascular control and is up-regulated under various conditions, including hypertension and menopause. The aim of this study was to evaluate the effects of swimming training and estrogen therapy (ET) on angiotensin-II (ANG II)-induced vasoconstriction and angiotensin-(1-7) [ANG-(1-7)]-induced vasorelaxation in aortic rings from ovariectomized spontaneously hypertensive rats. Animals were divided into Sham (SH), Ovariectomized (OVX), Ovariectomized treated with E2 (OE2), Ovariectomized plus swimming (OSW) and Ovariectomized treated with E2 plus swimming (OE2 + SW) groups. ET entailed the administration of 5 μg of 17β-Estradiol three times per week. Swimming was undertaken for sixty minutes each day, five times per week. Both, training and ET were initiated seven days following ovariectomy. Forty-eight hours after the last treatment or training session, the animals' systolic blood pressures were measured, and blood samples were collected to measure plasma ANG II and ANG-(1-7) levels via radioimmunoassay. In aortic rings, the vascular reactivity to ANG II and ANG-(1-7) was assessed. Expression of ANG-(1-7) in aortic wall was analyzed by immunohistochemistry. The results showed that both exercise and ET increased plasma ANG II levels despite attenuating systolic blood pressure. Ovariectomy increased constrictor responses to ANG II and decreased dilatory responses to ANG-(1-7), which were reversed by swimming independently of ET. Moreover, it was observed an apparent increase in ANG-(1-7) content in the aorta of the groups subjected to training and ET. Exercise training may play a cardioprotective role independently of ET and may be an alternative to ET in hypertensive postmenopausal women.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 87, January 2017, Pages 41-49
Journal: Peptides - Volume 87, January 2017, Pages 41-49
نویسندگان
Patrick W. Endlich, Erick R.G. Claudio, Leandro C.F. Lima, Rogério F. Ribeiro Júnior, Antonio A.B. Peluso, Ivanita Stefanon, Nazaré S. Bissoli, Virginia S. Lemos, Robson A.S. dos Santos, Glaucia R. de Abreu,