کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5514996 1400742 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleThe application of skin metabolomics in the context of transdermal drug delivery
ترجمه فارسی عنوان
بررسی اثر استفاده از متابولومن پوست در زمینه تحویل داروی ترمیمی
کلمات کلیدی
پوست، متابولومیکس، تحویل داروی ترانس خراب، بیومارکر، تکنیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Metabolomics is a powerful emerging tool for the identification of biomarkers and the exploration of metabolic pathways in a high-throughput manner. As an administration site for percutaneous absorption, the skin has a variety of metabolic enzymes, except other than hepar. However, technologies to fully detect dermal metabolites remain lacking. Skin metabolomics studies have mainly focused on the regulation of dermal metabolites by drugs or on the metabolism of drugs themselves. Skin metabolomics techniques include collection and preparation of skin samples, data collection, data processing and analysis. Furthermore, studying dermal metabolic effects via metabolomics can provide novel explanations for the pathogenesis of some dermatoses and unique insights for designing targeted prodrugs, promoting drug absorption and controlling drug concentration. This paper reviews current progress in the field of skin metabolomics, with a specific focus on dermal drug delivery systems and dermatosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 2, April 2017, Pages 252-259
نویسندگان
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