کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5517106 1543047 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular techniques for the personalised management of patients with chronic myeloid leukaemia
ترجمه فارسی عنوان
تکنیک های مولکولی برای مدیریت شخصی بیماران مبتلا به لوسمی مزمن میلوئیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی

Chronic myeloid leukemia (CML) is the paradigm for targeted cancer therapy. RT-qPCR is the gold standard for monitoring response to tyrosine kinase-inhibitor (TKI) therapy based on the reduction of blood or bone marrow BCR-ABL1. Some patients with CML and very low or undetectable levels of BCR-ABL1 transcripts can stop TKI-therapy without CML recurrence. However, about 60 percent of patients discontinuing TKI-therapy have rapid leukaemia recurrence. This has increased the need for more sensitive and specific techniques to measure residual CML cells. The clinical challenge is to determine when it is safe to stop TKI-therapy. In this review we describe and critically evaluate the current state of CML clinical management, different technologies used to monitor measurable residual disease (MRD) focus on comparingRT-qPCR and new methods entering clinical practice. We discuss advantages and disadvantages of new methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomolecular Detection and Quantification - Volume 11, March 2017, Pages 4-20
نویسندگان
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