کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5519694 1544410 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila
چکیده انگلیسی

We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A + T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For example, high mtDNA copy number correlates with longer development times. Our findings support the hypothesis that mtDNA copy number is modulated by mtDNA genome variation and suggest that it affects OXPHOS efficiency through changes in the organization of the respiratory membrane complexes to influence organismal phenotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 34, May 2017, Pages 75-83
نویسندگان
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