PerspectiveFeatureAm I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity

- Drugs carry proarrhythmic propensity.
- Drugs are categorized into various risk classes according to risk.
- The classifications are used for model development.
- Drug proarrhythmia risk classifications can be confusing and ambiguous.

This review aims to present and compare various Torsade de pointes propensity classification schemes of drugs that are publicly available from many scientific sources. We have also tracked and listed the compounds that were differently categorized. Additionally, we would like to draw attention to the need for establishing a general, standardized classification of a drug's proarrhythmic propensity. This is especially important in the current drug development process because of the changing paradigm of drug cardiac safety assessment.