ReviewKeynoteMarine pharmacology: therapeutic targeting of matrix metalloproteinases in neuroinflammation

- MMPs have a pivotal role in central nervous system development and physiology.
- MMPs are involved in the pathogenesis of brain diseases and in neuroinflammation.
- MMPs can be modulated by drugs and natural compounds.
- Several molecules with anti-MMP activity have been isolated from marine organisms.
- Marine natural products can be used in neuroinflammation management and treatment.

Alterations in matrix metalloproteinase (MMP) expression and activity are recognized as key pathogenetic events in several neurological disorders. This evidence makes MMPs possible therapeutic targets. The search for substances that can inhibit MMPs is moving progressively toward the screening of natural products. In particular, marine bioprospecting could be promising for the discovery of marine natural products with anti-MMP activities. Despite recent advances in this field, the possibility of using marine MMP inhibitors (MMPIs) for the treatment of neuroinflammation is still under-investigated. Here, we review the latest findings in this promising research field and the potential that marine MMPIs can have in the management and treatment of various neurological diseases.