کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5523944 1401399 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The importance of the tissue microenvironment in hairy cell leukemia
ترجمه فارسی عنوان
اهمیت محیط میکروسکوپ بافت در لوسمی سلول های موی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Hairy cell leukemia (HCL) cells engage in complex cellular and molecular interactions with accessory cells, matrix proteins, and various cytokines in the bone marrow and spleen, collectively referred to as the tissue microenvironment. Chemokine receptors and adhesion molecules are critical players for homing and retention within these microenvironments. Engagement of B cell antigen receptors and CD40 on HCL cells promote survival and proliferation. In this chapter, we summarize the current knowledge about the cellular and molecular interactions between HCL cells and their supportive tissue microenvironment, and provide insight into new therapeutic approaches targeting B cell receptor signaling in HCL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 28, Issue 4, December 2015, Pages 208-216
نویسندگان
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