کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5524001 1401403 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewHarnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
ReviewHarnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
چکیده انگلیسی

Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1868, Issue 1, August 2017, Pages 109-116
نویسندگان
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