Keywords: تیروزین کینازهای گیرنده ای; ADT; Androgen deprivation therapy; AR; Androgen receptor; CRPC; Castration resistant prostate cancer; DHT; Dihydrotestosterone; EGF; Epidermal growth factor; EMT; Epithelial mesenchymal transition; ERβ; Estrogen receptor β; FGF; Fibroblast growth factor
مقالات ISI تیروزین کینازهای گیرنده ای (ترجمه نشده)
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Keywords: تیروزین کینازهای گیرنده ای; RTK; receptor tyrosine kinase; TKL; tyrosine kinase-like receptor; GPI-AP; glycosylphosphatidylinositol-anchored protein; SH2; Scr homology 2 domain; TMD; transmembrane domain; ECD; extracellular domain or ectodomain; ICD; intracellular domain; JM; juxtam
Keywords: تیروزین کینازهای گیرنده ای; EGFR; epidermal growth factor receptor; EGF; epidermal growth factor; MAP kinase; mitogen-activated protein kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; Mut R1-6; EGFR mutant with six residues mutated to alanines in the juxtamembrane segment; PL
Keywords: تیروزین کینازهای گیرنده ای; BM; basement membrane; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; FA; focal adhesion; HD; hemidesmosome; IAP; integrin associated protein; RTK; receptor tyrosine kinase; SFK; Src family kinase; TEM; tetraspanin-enriched microdomain
Structural characterization of recombinant human fibroblast growth factor receptor 2b kinase domain upon interaction with omega fatty acids
Keywords: تیروزین کینازهای گیرنده ای; hFGFR2b; human fibroblast growth factor receptor 2b; UFAs; unsaturated fatty acids; CD; circular dichroism; FGFRs; fibroblast growth factor receptors; RTK; receptor tyrosine kinase; Ig; immunoglobulin; PLCγ; phospholipase Cγ; FRS2; fibroblast growth fac
Keywords: تیروزین کینازهای گیرنده ای; BP; bitopic protein; RTK; receptor tyrosine kinase; TMD; transmembrane domain; JM; juxtamembrane; ECD; extracellular domain; ICD; intracellular domain; NMR; nuclear magnetic resonance; MD; molecular dynamics; LID; “ligand-induced dimerization” mechani
Keywords: تیروزین کینازهای گیرنده ای; Diarylurea; Multi-target; Receptor tyrosine kinase; Inhibitor; Structural diversity
Keywords: تیروزین کینازهای گیرنده ای; Heart failure; antineoplastic drugs-induced cardiotoxicity; anthracyclines; receptor tyrosine kinase
Keywords: تیروزین کینازهای گیرنده ای; FGFR; FGF ligand; EGFR; Receptor tyrosine kinase; Targeted therapy;
Keywords: تیروزین کینازهای گیرنده ای; ARDS; acute respiratory distress syndrome; AHR; airway hyperresponsiveness; ASM; airway smooth muscle; BAL; bronchoalveolar lavage; CPA; carboxypeptidase A; CADM1; cell adhesion molecule 1; COPD; chronic obstructive pulmonary disease; NADPH; dihydronicoti
Keywords: تیروزین کینازهای گیرنده ای; Angiogenesis; Endothelial cells; Gab1; Receptor tyrosine kinase; Tyrosine phosphorylation;
Keywords: تیروزین کینازهای گیرنده ای; SM; systemic mastocytosis; AHNMD; associated clonal haematological non-mast cell lineage disease; CM; cutaneous mastocytosis; RTK; receptor tyrosine kinase; MDS; myelodysplastic syndrome; MPN; myeloproliferative syndrome; AML; acute myeloid leukaemia.; Ma
Keywords: تیروزین کینازهای گیرنده ای; G-protein-coupled receptor; Receptor tyrosine kinase; Endocytosis; Internalization; NanoLucGPCR, G-protein-coupled receptor; RTK, receptor tyrosine kinase; Nluc, NanoLuc; EGFR, epidermal growth factor receptor; PCR, polymerase chain reaction; ISO, isoprot
Keywords: تیروزین کینازهای گیرنده ای; Small cell lung cancer; Receptor tyrosine kinase; Angiogenesis; Apoptosis; Epigenetics; Immunotherapy
Keywords: تیروزین کینازهای گیرنده ای; Bone metastasis; Bone sarcoma; Receptor tyrosine kinase; Growth factor; Inhibitor; Therapy
Keywords: تیروزین کینازهای گیرنده ای; CD117; Stem Cell Factor; Colorectal Cancer; Enteroids; Cy; cyanine; FACS; fluorescence-activated cell sorting; LGR5; leucine-rich repeat-containing G-protein coupled receptor 5; NSG; NOD-scid IL2Rgnull; qRT-PCR; quantitative reverse transcription polymer
Keywords: تیروزین کینازهای گیرنده ای; Breast cancer; Targeted therapy; Meta-analysis; Overexpression; Prognosis; Receptor tyrosine kinase;
Keywords: تیروزین کینازهای گیرنده ای; ALI; acute lung injury; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; LPS; lipopolysaccharide; MMP; matrix metalloproteinase; NRTK; nonreceptor tyrosine kinase; PDGF; platelet-derived growth factor; PDGFR; platelet-derived growth fact
Keywords: تیروزین کینازهای گیرنده ای; 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr
Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma
Keywords: تیروزین کینازهای گیرنده ای; Clear cell renal cell carcinoma; EphA3; Receptor tyrosine kinase;
ReviewMUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas
Keywords: تیروزین کینازهای گیرنده ای; MUC1; mucin 1; MUC1-C; MUC1 C-terminal subunit; EMT; epithelial-mesenchymal transition; MUC1-N; MUC1 N-terminal subunit; RTK; receptor tyrosine kinase; EMT-TF; EMT-inducing transcription factor; PRC1; polycomb repressive complex 1; DNMT; DNA methyltransfe
Discovering novel 7-azaindole-based series as potent AXL kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; AXL; 7-Azaindole; Receptor tyrosine kinase; Kinase inhibitor; Modeling study; Medicinal chemistry;
ReviewHarnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
Keywords: تیروزین کینازهای گیرنده ای; Leucine-rich repeats and immunoglobulin-like domains containing protein 1; Receptor tyrosine kinase; Ectodomain; Nervous system; Cancer;
Full length articleIdentification and first characterization of SmEps8, a potential interaction partner of SmTK3 and SER transcribed in the gonads of Schistosoma mansoni
Keywords: تیروزین کینازهای گیرنده ای; Schistosoma mansoni; Gonad; Signal transduction; Kinase; Eps8; EGFR; dia; diaphanous; EGFR; epidermal growth factor receptor; PK; protein kinases; PTB; phosphotyrosine binding domain; RTK; receptor tyrosine kinase; SH; Src homology; TK; tyrosine kinase; Y
Original ArticleAG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization
Keywords: تیروزین کینازهای گیرنده ای; Anticancer compound; Mitochondrial metabolism; Electron transport chain; Hypoxia; NADH-ubiquinone oxidoreductase; NADH; nicotinamide adenine dinucleotide; RTK; receptor tyrosine kinase; TS; thymidylate synthase; CCS; cosmic calf serum; DMSO; dimethyl sulf
Alternative polyadenylation expands the mRNA isoform repertoire of human CD46
Keywords: تیروزین کینازهای گیرنده ای; 5â²ss; 5â² splice site; 3â²RACE; 3â² Rapid Amplification of cDNA Ends; 3â²UTR; 3â² UnTranslated Region; APA; Alternative PolyAdenylation; ASO; AntiSense Oligonucleotide; CCP; Complement Control Protein; CD46; Cluster of Differentiation gene 46; CD46
Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation
Keywords: تیروزین کینازهای گیرنده ای; HETE; hydroxyeicosatetraenoic acid; LN; laminin; RTK; receptor tyrosine kinase; AA; arachidonic acid; pSFK; phospho Src family kinase; AA; Arachidonic acid; PTPase; protein tyrosine phosphatase; IP; immunoprecipitation; LC-MS; Liquid chromatography-mass s
ReviewScaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow
Keywords: تیروزین کینازهای گیرنده ای; PKA; protein kinase A; PI3K; phosphoinositide 3-kinase; PtdIns; phosphatidylinositols; RTK; receptor tyrosine kinase; GPCR; G-protein-coupled receptor; PIP3; PtdIns (3,4,5)-triphosphate; PI3Kγ; phosphoinositide 3-kinase γ; βAR; β-adrenergic receptor;
Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; c-Met; Receptor tyrosine kinase; Anti-tumor; 7-Azaindole derivatives; Dihydropyridazine;
Strategies for development of optogenetic systems and their applications
Keywords: تیروزین کینازهای گیرنده ای; AU1; Aureochrome 1; BLUF; blue-light-utilizing FAD; BphP1; bacterial bathy phytochrome 1; BV; biliverdin IXα; COP1; constitutively photomorphogenic 1; CRY2; cryptochrome 2; CIB1; cryptochrome interacting basic-helix-loop-helix protein 1; CPH1; cyanobacte
Alkaline pH induces IRR-mediated phosphorylation of IRS-1 and actin cytoskeleton remodeling in a pancreatic beta cell line
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Protein phosphorylation; Membrane proteins; Insulin; Alkaline pH;
The SAM domain inhibits EphA2 interactions in the plasma membrane
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; EphA2; SAM domain; Interactions;
Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer
Keywords: تیروزین کینازهای گیرنده ای; DDR1; discoidin domain receptor 1; DDR2; discoidin domain receptor 2; EMT; epithelial-mesenchymal transition; EOC; epithelial ovarian cancer; RT-qPCR; reverse transcription quantitative polymerase chain reaction; ELISA; enzyme-linked immunosorbent assay;
Dual signaling evoked by oxidized LDLs in vascular cells
Keywords: تیروزین کینازهای گیرنده ای; AAPH; 2,2'-azobis(2-amidinopropane) dihydrochloride; AIF; apoptotic inducing factor; AMVN; 2,4-dimethylvaleronitrile; AP-1; activator protein 1; ATF6; activating transcription factor 6; CDE; clathrin-dependent endocytosis; CCL2; chemokine ligand 2 (or MCP
Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition
Keywords: تیروزین کینازهای گیرنده ای; Cancer Stem Cell (CSC); Targeted Therapy; Biologic; Anti-Tumor Agent; CSC; cancer stem cell; EAC; esophageal adenocarcinoma; EMT; epithelial to mesenchymal transition; Erb-b2/HER/ERBB; human epidermal growth factor receptor; FACS; fluorescence-activated c
Optogenetics - Bringing light into the darkness of mammalian signal transduction
Keywords: تیروزین کینازهای گیرنده ای; AsLOV2; Avena sativa light-oxygen-voltage domain 2; ChR2; Channelrhodopsin-2; CIB1; Chryptochrome-interacting basic helix-loop-helix 1; CIBN; N-terminus of CIB1; COP1; Constitutive photomorphogenesis protein 1; CPH1; Cyanobacterial phytochrome 1; CRY2; Cr
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: تیروزین کینازهای گیرنده ای; AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
MC1R signaling. Intracellular partners and pathophysiological implications
Keywords: تیروزین کینازهای گیرنده ای; AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; ARRB; β-arrestin; ASIP; agouti signal protein; CBD103; dog β-defensin-3; CREB; cAMP responsive-element binding protein; EDN1; endothelin 1; ER; endoplasmic reticulum; ERK; extracellular signal-reg
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation
Keywords: تیروزین کینازهای گیرنده ای; 4ICD; HER4 intracellular domain; ATCC; American type culture collection; EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; EGFR; epidermal growth factor family; ERα; estrogen receptor alpha; FBS; fetal bovine serum; HEK; human embry
Discovery of an artificial peptide agonist to the fibroblast growth factor receptor 1c/βKlotho complex from random peptide T7 phage display
Keywords: تیروزین کینازهای گیرنده ای; Peptide; Agonist; FGFR; βKlotho; FGF21; Phage display; FGFR; fibroblast growth factor receptor; KLB; βKlotho; FGF21; fibroblast growth factor 21; PEG; polyethyleneglycol; Egr-1; early growth response protein-1; RTK; receptor tyrosine kinase;
c-Met expression and MET amplification in malignant pleural mesothelioma
Keywords: تیروزین کینازهای گیرنده ای; c-Met; Mesothelioma; MET; Receptor tyrosine kinase; Tyrosine kinase inhibitor
The relationship between prenatal exposure to BP-3 and Hirschsprung's disease
Keywords: تیروزین کینازهای گیرنده ای; Benzophenone-3; Hirschsprung's disease; Receptor tyrosine kinase; miR-218; Migration; Pathway; HSCR; Hirschsprung's disease; BP-3; Benzophenone-3; RET; receptor tyrosine kinase; DMSO; dimethyl sulfoxide; SDS; sodium dodecyl sulfate; DEPC; diethylpyrocarbo
CommunicationsPathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure
Keywords: تیروزین کینازهای گیرنده ای; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; TM; transmembrane; EC; extracellular; RTK; receptor tyrosine kinase; QI-FRET; quantitative imaging FRET; I-FRET; intrinsic FRET; IC; intracellular; YFP; yellow fluorescent protein; FG
IGF1R and c-met as therapeutic targets for colorectal cancer
Keywords: تیروزین کینازهای گیرنده ای; Colorectal cancer; IGF1R; c-Met; Receptor tyrosine kinase
Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues
Keywords: تیروزین کینازهای گیرنده ای; Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily
Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion
Keywords: تیروزین کینازهای گیرنده ای; EMT; epithelial-mesenchymal transition; GPCR; G protein-coupled receptor; HINT; histidine triad nucleotide binding protein; RTK; receptor tyrosine kinase; RGS; regulator of G protein signaling; TLR; Toll-like receptor; RGS20; Cancer; Tumorigenesis; Metast
BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation
Keywords: تیروزین کینازهای گیرنده ای; DAG; diacylglycerol; PPIns; phosphoinositides; RTK; receptor tyrosine kinase; GPCR; G-protein coupled receptor; Ins(1,4,5)P3; inositol 1,4,5-trisphosphate; PM; plasma membrane; BRET; bioluminescence resonance energy transfer; PLC; phospholipase C; PtdIns(
Molecular mechanisms of LL-37-induced receptor activation: An overview
Keywords: تیروزین کینازهای گیرنده ای; AMP; antimicrobial peptide; APD; antimicrobial peptide database; IFN; interferon; DC; dendritic cell; NK-cells; natural killer cells; GPCR; G protein-coupled receptor; RTK; receptor tyrosine kinase; LGIC; ligand-gated ion channel; TLR; toll-like receptor;
ReviewRegulation, Signaling, and Physiological Functions of G-Proteins
Keywords: تیروزین کینازهای گیرنده ای; GPCR; G-protein-coupled receptor; G-protein; guanine-nucleotide-binding regulatory proteins; β2-AR; β2-adrenergic receptor; GPR; G-protein regulator; GBA; Gα-binding and activating; RGS; regulators of G-protein signaling; RTK; receptor tyrosine kinase;
Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation
Keywords: تیروزین کینازهای گیرنده ای; YAP1; Yes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; eIF4E; eukaryotic translation initiation factor 4E; PI3K; phosphatidylinositide-3-kinase; WNT; Wingless-type mouse mammary tumor virus integration site family m