MET receptor tyrosine kinase as a therapeutic anticancer target
Keywords: تیروزین کینازهای گیرنده ای; Met; Receptor tyrosine kinase; Targeted therapy; Hepatocyte growth factor
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Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Pyrazolopyrimidines; erbB2; Receptor tyrosine kinase
KIT and FLT3 receptor tyrosine kinase mutations in acute myeloid leukemia with favorable cytogenetics: Two novel mutations and selective occurrence in leukemia subtypes and age groups
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Acute myeloid leukemia; KIT; FLT3; Novel mutations; Immunophenotypes
Autocrine NGFβ/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines
Keywords: تیروزین کینازهای گیرنده ای; Hodgkin lymphoma; Receptor tyrosine kinase; TRKA; NGFb; K-252a; AKT
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; ErbB-2; EGFR; Hydrazones; Quinazoline; Bioisostere
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; ErbB-2; EGFR; Oxime; Quinazoline; Bioisostere
A new Met inhibitory-scaffold identified by a focused forward chemical biological screen
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Met-antagonist; Neoplastic transformation; Chemical biological screening; Computer modelling
Stem cell factor induces HIF-1α at normoxia in hematopoietic cells
Keywords: تیروزین کینازهای گیرنده ای; Stem cell factor; c-Kit; Affymetrix; HIF-1α; Hypoxia; Receptor tyrosine kinase
Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes
Keywords: تیروزین کینازهای گیرنده ای; APRPG-PEG-Lip-SU1498; APRPG-PEG-modified liposomal SU1498; DDS; drug delivery systems; DPPC; dipalmitoylphosphatidylcholine; DPPG; dipalmitoylphosphatidylglycerol; DSPE-PEG-APRPG; distearoylphosphatidylethanolamine-polyethyleneglycol-APRPG peptide conjuga
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Met; Receptor tyrosine kinase; Protein kinase inhibitors
βγ subunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced
Keywords: تیروزین کینازهای گیرنده ای; BDNF; brain-derived neurotrophic factor; CTX; cholera toxin; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EPAC; exchange protein activated by cAMP; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; G3
3D-QSAR CoMFA analysis of C5 substituted pyrrolotriazines as HER2 (ErbB2) inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; EGFR; Human epidermal growth factor receptor; CoMFA
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole
Keywords: تیروزین کینازهای گیرنده ای; 1H-Imidazol-2-ylamine; Pyrimidine; Receptor tyrosine kinase; PDGFR; Bioisosterism
Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib
Keywords: تیروزین کینازهای گیرنده ای; Chronic myelogenous leukemia; Discoidin domain; Fibrosis; Gleevec; Receptor tyrosine kinase; Tasigna
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2
Keywords: تیروزین کینازهای گیرنده ای; Kinase inhibitor; Angiogenesis; VEGFR2; Tie-2; Receptor tyrosine kinase
Altered EphA5 mRNA expression in rat brain with a single methamphetamine treatment
Keywords: تیروزین کینازهای گیرنده ای; Methamphetamine; Associative learning; Dependence; Neuronal plasticity; Synaptic connectivity; Receptor tyrosine kinase
ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2
Keywords: تیروزین کینازهای گیرنده ای; Vascular endothelial growth factor receptor; KDR; VEGFR-2; VEGFR-1; Receptor tyrosine kinase; Dual kinase inhibitors; Angiogenesis
LRIG inhibitors of growth factor signalling – double-edged swords in human cancer?
Keywords: تیروزین کینازهای گیرنده ای; LRIG; EGFR; ErbB; Tumour suppressor; Receptor tyrosine kinase
Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates
Keywords: تیروزین کینازهای گیرنده ای; Vascular endothelial growth factor receptor-2; VEGFR-2; VEGFR-1; Receptor tyrosine kinase; Dual kinase inhibitors; Angiogenesis; 1-(2-(Pyridin-4-yl)ethyl)-1H-azole-5-carboxamides
Multiple variants of the RON receptor tyrosine kinase: Biochemical properties, tumorigenic activities, and potential drug targets
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Alternative splicing; Oncogenic signal; Invasive growth; Therapeutical target
Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM)
Keywords: تیروزین کینازهای گیرنده ای; EphA2; EphrinA1; Malignant mesothelioma; Receptor tyrosine kinase; Proliferation; ERK1/2
Definition of a direct extracellular interaction between Met and E-cadherin
Keywords: تیروزین کینازهای گیرنده ای; Hepatocyte growth factor; Met; E-cadherin; Receptor tyrosine kinase;
Silk fibroin mediated delivery of liposomal emodin to breast cancer cells
Keywords: تیروزین کینازهای گیرنده ای; Drug delivery; Liposome coating; Polymer; Breast cancer; Receptor tyrosine kinase
Loss of nitric oxide-mediated down-regulation of NMDA receptors in neurofilament aggregate-bearing motor neurons in vitro: Implications for motor neuron disease
Keywords: تیروزین کینازهای گیرنده ای; ALS; amyotrophic lateral sclerosis; CEE; chick embryo extract; DAB; 3,4-diaminobenzidine; L-NNA; NÏ-nitro-L-arginine; NaCN; sodium cyanide; NF; neurofilament; hNFL+/+; transgenic mice, overexpressing human low molecular weight neurofilament protein; nNOS
A versatile system for site-specific enzymatic biotinylation and regulated expression of proteins in cultured mammalian cells
Keywords: تیروزین کینازهای گیرنده ای; Biotin; Avidin; Streptavidin; Ubiquitin–protein ligase; Receptor tyrosine kinase; Doxycycline-regulated expression
Mammalian collagen receptors
Keywords: تیروزین کینازهای گیرنده ای; Collagen; Triple helix; Integrin; Receptor tyrosine kinase; Cell adhesion; Hemostasis
Targeting mTOR signaling in lung cancer
Keywords: تیروزین کینازهای گیرنده ای; Non-small cell lung cancer; Small cell lung cancer; Mammalian target of rapamycin; Phosphoinositide 3-kinase; Akt; Epidermal growth factor receptor; Receptor tyrosine kinase
Characterization and development of a peptide substrate-based phosphate transfer assay for the human vascular endothelial growth factor receptor-2 tyrosine kinase
Keywords: تیروزین کینازهای گیرنده ای; VEGF; Kdr; Receptor tyrosine kinase; Phosphorylation assay; Autophosphorylation; Angiogenesis; Kinase domain
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones
Keywords: تیروزین کینازهای گیرنده ای; Bisbenzofuranylmethanone; Receptor tyrosine kinase; FLT3; PDGFR; Bisindolylmethanone; Benzofuranylindolylmethanone
EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph
Keywords: تیروزین کینازهای گیرنده ای; Ephrin-B2; EphB2; Receptor tyrosine kinase; Vestibular epithelium; Dark cells; Transitional cells; Endolymph; Potassium; Ionic homeostasis
Receptor tyrosine kinase inhibitors AG013764 and AG013711 reduce choroidal neovascularization in rat eye
Keywords: تیروزین کینازهای گیرنده ای; age-related macular degeneration; choroidal neovascularization; gene transfer; adeno-associated viral vector; anti-angiogenesis; receptor tyrosine kinase; VEGF; PDGF; combination therapy
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
Keywords: تیروزین کینازهای گیرنده ای; Bad phosphorylation; JNK; Akt; SP600125; bpV(pic); Cerebral ischemia; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; ERK; Extracellular signal regulated kinase; PKA; protein kinase A; RTK; receptor t
Dimerization of VEGF receptors and implications for signal transduction: A computational study
Keywords: تیروزین کینازهای گیرنده ای; Homodimer; Heterodimer; Growth factor; Receptor tyrosine kinase; Mathematical model;
Targeting receptor tyrosine kinase signaling in acute myeloid leukemia
Keywords: تیروزین کینازهای گیرنده ای; AML; Receptor tyrosine kinase; Flt3; c-Kit; IGF-IR; PI3K; mTOR
Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): What have we learned so far?
Keywords: تیروزین کینازهای گیرنده ای; Small cell lung cancer; Receptor tyrosine kinase; Gefitinib; Gleevec; c-Kit; Insulin-like growth factor receptor; Epidermal growth factor receptor; Phosphoinositide 3-kinase; Mammalian target of rapamycin; Ras
Mutant Tie2 causing venous malformation signals through Shc
Keywords: تیروزین کینازهای گیرنده ای; Endothelial; Receptor tyrosine kinase; Adaptor protein
Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Kinase inhibition; EGFR; ErbB2; Medicinal chemistry
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Cancer; Receptor tyrosine kinase; KDR kinase; Inhibitor; 1,4-Dihydroindeno[1,2-c]pyrazoles
Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development
Keywords: تیروزین کینازهای گیرنده ای; Eph; Ephrin; Epha1; Efna1; Efna3; Receptor tyrosine kinase; Implantation; Gastrulation; Neurulation; Somitogenesis; Organogenesis; Embryogenesis
ErbB-4 and TNF-α converting enzyme localization to membrane microdomains
Keywords: تیروزین کینازهای گیرنده ای; ErbB-4; Receptor tyrosine kinase; Tumor necrosis factor-α converting enzyme; Lipid rafts; Membrane microdomains
Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors I and II
Keywords: تیروزین کینازهای گیرنده ای; Vascular endothelial growth factor receptor 2; Receptor tyrosine kinase; Dual kinase inhibitor; Angiogenesis; 4-(Azolylethyl)thiazole-5-carboxamides
2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: Novel dual inhibitors of VEGFR-1/2 kinases
Keywords: تیروزین کینازهای گیرنده ای; Vascular endothelial growth factor receptor 2; Receptor tyrosine kinase; Dual kinase inhibitor; Angiogenesis; 2-((1H-Azol-1-yl)methyl)-N-arylbenzyl amides
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
Keywords: تیروزین کینازهای گیرنده ای; Cancer; Receptor tyrosine kinase; KDR kinase; Inhibitor; 1,4-Dihydroindeno[1,2-c]pyrazole
Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases
Keywords: تیروزین کینازهای گیرنده ای; Naphthofuroquinone; Receptor tyrosine kinase; Docking study
Expression and purification of the intact cytoplasmic domain of the human ephrin receptor A2 tyrosine kinase in Escherichia coli
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Kinase expression
Gastrointestinal stromal tumor (GIST) pathogenesis, familial GIST, and animal models
Keywords: تیروزین کینازهای گیرنده ای; GIST; KIT; PDGFRA; Receptor tyrosine kinase; Signal transduction;
Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template
Keywords: تیروزین کینازهای گیرنده ای; Vascular endothelial growth factor receptor 2; VEGFR-2; VEGFR-1; Receptor tyrosine kinase; Dual kinase inhibitors; Angiogenesis; ((Pyridin-4-yl)ethyl)pyridines
Transmembrane Helix Heterodimerization in Lipid Bilayers: Probing the Energetics behind Autosomal Dominant Growth Disorders
Keywords: تیروزین کینازهای گیرنده ای; heterodimer; FRET; receptor tyrosine kinase; fibroblast growth factor receptor 3; transmembrane domainTM, transmembrane; RTK, receptor tyrosine kinase; FGFR3, fibroblast growth factor receptor 3; FRET, Förster resonance energy transfer
Molecular pathology of gliomas
Keywords: تیروزین کینازهای گیرنده ای; Glioma; Glioblastoma; Astrocytoma; EGFR; KIT; PDGFR; Receptor tyrosine kinase
HGF/SF Increases Tumor Blood Volume: A Novel Tool for the In Vivo Functional Molecular Imaging of Met
Keywords: تیروزین کینازهای گیرنده ای; Receptor tyrosine kinase; Met; hepatocyte growth factor/scatter factor; functional molecular imaging; contrast medium ultrasound;