کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1378666 | 982006 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors 1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors](/preview/png/1378666.png)
چکیده انگلیسی
A series of 1,4-dihydroindeno[1,2-c]pyrazoles with a 3-thiophene substituent carrying a urea-type side chain were identified as potent multitargeted (VEGFR and PDGFR families) receptor tyrosine kinase inhibitors. A KDR homology model suggested that the urea moiety is able to interact with a recognition motif in the hydrophobic specificity pocket of the enzyme.
A series of 1,4-dihydroindeno[1,2-c]pyrazoles with urea-type side chains was identified as potent multitargeted (VEGFR and PDGFR families) receptor tyrosine kinase inhibitors. A KDR homology model suggested that the urea moiety is able to interact with a recognition motif in the hydrophobic specificity pocket of the enzyme.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 16, 15 August 2006, Pages 4266–4271
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 16, 15 August 2006, Pages 4266–4271
نویسندگان
Jürgen Dinges, Kimba L. Ashworth, Irini Akritopolou-Zanze, Lee D. Arnold, Steven A. Baumeister, Peter F. Bousquet, George A. Cunha, Steven K. Davidsen, Stevan W. Djuric, Vijaya J. Gracias, Michael R. Michaelides, Paul Rafferty, Thomas J. Sowin,