کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5509413 | 1400457 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion
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کلمات کلیدی
GPCRTLRRGSRTKTumorigenesis - تومورزاییEMT - تکنسین فوریتهای پزشکیRTK, Receptor tyrosine kinase - تیروزین کینازهای گیرنده ایToll-like receptor - تیالآرRegulator of G protein signaling - رگولاتور سیگنالینگ پروتئین GCancer - سرطانMetastasis - متاستاز HINT - نکتهEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیG protein-coupled receptor - گیرندههای جفتشونده با پروتئین جی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Several RGS (regulator of G protein signaling) proteins are known to be upregulated in a variety of tumors but their roles in modulating tumorigenesis remain undefined. Since the expression of RGS20 is elevated in metastatic melanoma and breast tumors, we examined the effects of RGS20 overexpression and knockdown on the cell mobility and adhesive properties of different human cancer cell lines, including cervical cancer HeLa, breast adenocarcinoma MDA-MB-231, and non-small cell lung carcinoma H1299 and A549 cells. Expression of RGS20 enhanced cell aggregation, migration, invasion and adhesion as determined by hanging drop aggregation, wound healing, transwell chamber migration and invasion assays. Conversely, shRNA-mediated knockdown of endogenous RGS20 impaired these responses. In addition, RGS20 elevated the expression of vimentin (a mesenchymal cell marker) but down-regulated the expression of E-cadherin, two indicators commonly associated with metastasis. These results suggest that the expression of RGS20 may promote metastasis of tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 28, Issue 11, November 2016, Pages 1663-1672
Journal: Cellular Signalling - Volume 28, Issue 11, November 2016, Pages 1663-1672
نویسندگان
Lei Yang, Maggie M.K. Lee, Manton M.H. Leung, Yung H. Wong,