کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5954602 | 1173318 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Matrix Metalloproteinases and Protein Tyrosine Kinases
ترجمه فارسی عنوان
متالوپروتئیناتهای ماتریکس و پروتئین تیروزین کیناز
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کلمات کلیدی
nonreceptor tyrosine kinasePDGFRRTKVEGFRECMPDGFSFKLPSPTKMMPNRTKEGFRSrc family kinase - kinase family SrcAcute lung injury - آسیب ریه حادVentilator-induced lung injury - آسیب ریه ناشی از تهویهAli - اماRTK, Receptor tyrosine kinase - تیروزین کینازهای گیرنده ایVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)platelet-derived growth factor - فاکتور رشد حاصل از پلاکتlipopolysaccharide - لیپوپلی ساکاریدExtracellular matrix - ماتریکس خارج سلولیmatrix metalloproteinase - ماتریکس متالوپروتئینازVILI - ویلیProtein tyrosine kinase - پروتئین تیروزین کینازplatelet-derived growth factor receptor - گیرنده عامل فاکتور رشد یافته پلاکتvascular endothelial growth factor receptor - گیرنده فاکتور رشد اندوتلیال عروقیEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Acute lung injury (ALI) and ARDS fall within a spectrum of pulmonary disease that is characterized by hypoxemia, noncardiogenic pulmonary edema, and dysregulated and excessive inflammation. While mortality rates have improved with the advent of specialized ICUs and lung protective mechanical ventilation strategies, few other therapies have proven effective in the management of ARDS, which remains a significant clinical problem. Further development of biomarkers of disease severity, response to therapy, and prognosis is urgently needed. Several novel pathways have been identified and studied with respect to the pathogenesis of ALI and ARDS that show promise in bridging some of these gaps. This review will focus on the roles of matrix metalloproteinases and protein tyrosine kinases in the pathobiology of ALI in humans, and in animal models and in vitro studies. These molecules can act independently, as well as coordinately, in a feed-forward manner via activation of tyrosine kinase-regulated pathways that are pivotal in the development of ARDS. Specific signaling events involving proteolytic processing by matrix metalloproteinases that contribute to ALI, including cytokine and chemokine activation and release, neutrophil recruitment, transmigration and activation, and disruption of the intact alveolar-capillary barrier, will be explored in the context of these novel molecular pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 146, Issue 4, October 2014, Pages 1081-1091
Journal: Chest - Volume 146, Issue 4, October 2014, Pages 1081-1091
نویسندگان
Yael MD, Rachel L. MD, Cory M. MD, Gregory P. MD, FCCP,