کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5529198 | 1401687 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Short CommunicaitonTumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases Short CommunicaitonTumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases](/preview/png/5529198.png)
IntroductionRecently TRG, necrosis grade and the rate of viable cancer cells of colorectal liver metastases were correlated with the response to chemotherapy treatments, whereas K-RAS mutations and c-MET over-expression were correlated with the prognosis.Methods58 resection specimens were assessed for regression grades. Patients undergone neo-adjuvant treatments were compared to patients who underwent therapy exclusively adjuvantly. We investigated the K-RAS mutational profile, the c-MET over-expression along with patients' survivals curves.ResultsPatients undergone neo-adjuvant treatment presented significant higher fibrosis rates and lower rates of viable cells. 36.7% of the patients had a K-RAS mutation and the 26.7% presented c-MET over-expression, but these features did not correlate with patients' clinical/pathological data. Survival analysis documented that K-RAS WT patients presenting c-MET over-expression had worse outcomes.ConclusionFibrosis and the rate of viable cells significantly correlate with the response to chemotherapy treatments. c-MET is a promising marker in K-RAS WT patients.
Journal: Pathology - Research and Practice - Volume 213, Issue 8, August 2017, Pages 1002-1009