کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5529360 1401694 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleMicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Original articleMicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth
چکیده انگلیسی

Osteosarcoma is the most common type of bone cancer prevalent in young adults. Recent studies suggested that aberrant microRNA expression plays an essential role in osteosarcoma pathogenesis. In this study, we found miR-155 up-regulation in different osteosarcoma cell lines U2OS, Saos-2 and MG-63. Through bioinformatic prediction and analysis, we identified its target MAP3K10 that involved in cell proliferation and apoptosis. This work demonstrates novel interaction between microRNA, intercellular MAPK signaling and apoptosis in osteosarcoma, which will provide targets for therapeutic development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Research and Practice - Volume 213, Issue 4, April 2017, Pages 389-393
نویسندگان
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