کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5529791 | 1401707 | 2016 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Multiple training interventions significantly improve reproducibility of PET/CT-based lung cancer radiotherapy target volume delineation using an IAEA study protocol Multiple training interventions significantly improve reproducibility of PET/CT-based lung cancer radiotherapy target volume delineation using an IAEA study protocol](/preview/png/5529791.png)
Background and purposeTo assess the impact of a standardized delineation protocol and training interventions on PET/CT-based target volume delineation (TVD) in NSCLC in a multicenter setting.Material and methodsOver a one-year period, 11 pairs, comprised each of a radiation oncologist and nuclear medicine physician with limited experience in PET/CT-based TVD for NSCLC from nine different countries took part in a training program through an International Atomic Energy Agency (IAEA) study (NCT02247713). Teams delineated gross tumor volume of the primary tumor, during and after training interventions, according to a provided delineation protocol. In-house developed software recorded the performed delineations, to allow visual inspection of strategies and to assess delineation accuracy.ResultsFollowing the first training, overall concordance indices for 3 repetitive cases increased from 0.57 ± 0.07 to 0.66 ± 0.07. The overall mean surface distance between observer and expert contours decreased from â0.40 ± 0.03 cm to â0.01 ± 0.33 cm. After further training overall concordance indices for another 3 repetitive cases further increased from 0.64 ± 0.06 to 0.80 ± 0.05 (p = 0.01). Mean surface distances decreased from â0.34 ± 0.16 cm to â0.05 ± 0.20 cm (p = 0.01).ConclusionMultiple training interventions improve PET/CT-based TVD delineation accuracy in NSCLC and reduce interobserver variation.
Journal: Radiotherapy and Oncology - Volume 121, Issue 1, October 2016, Pages 39-45