کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5530669 | 1549390 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Insights into current problems in prevention and therapy for leishmaniasis.
- Prospects of lipid adjuvant delivery tools in leishmaniasis.
- Rationale for designing appropriate delivery system.
Disease management of leishmaniasis is appalling due to lack of a human vaccine and the toxicity and resistance concerns with limited therapeutic drugs. The challenges in development of a safe vaccine for generation and maintenance of robust antileishmanial protective immunity through a human administrable route of immunization can be addressed through immunomodulation and targeted delivery. The versatility of lipid based particulate system for deliberate delivery of diverse range of molecules including immunomodulators, antigens and drugs have essentially found pivotal role in design of proficient vaccination and therapeutic strategies against leishmaniasis. The prospects of lipid based preventive and curative formulations for leishmaniasis have been highlighted in this review.
Journal: Cellular Immunology - Volume 309, November 2016, Pages 55-60