کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5530703 | 1549384 | 2017 | 9 صفحه PDF | دانلود رایگان |
- Obesity cause of metabolic disturbances, due to changes in circulating cytokines.
- Pro-inflammatory cytokines lead to the metabolic issues e.g. insulin insensitivity.
- This review focuses the link between metabolism, immunity and insulin resistance.
The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ovarian disease and several types of cancers. Obesity is characterized by pro-inflammatory condition in which hypertrophied adipose tissue along with immune cells contribute to increase the level of pro-inflammatory cytokines. Immune cells are the key players in inducing low grade chronic inflammation in obesity and are main factor responsible for pathogenesis of insulin resistance resulting Type 2 diabetes. The current review is aimed to investigate the mechanism of pro-inflammatory responses and insulin resistance involving immune cells and their products in obesity.
Journal: Cellular Immunology - Volume 315, May 2017, Pages 18-26