کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5531786 1401814 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetics of enteric neuropathies
ترجمه فارسی عنوان
ژنتیک نوروپاتی عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Abnormal development or disturbed functioning of the enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is associated with the development of neuropathic gastrointestinal motility disorders. Here, we review the underlying molecular basis of these disorders and hypothesize that many of them have a common defective biological mechanism. Genetic burden and environmental components affecting this common mechanism are ultimately responsible for disease severity and symptom heterogeneity. We believe that they act together as the fulcrum in a seesaw balanced with harmful and protective factors, and are responsible for a continuum of symptoms ranging from neuronal hyperplasia to absence of neurons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 417, Issue 2, 15 September 2016, Pages 198-208
نویسندگان
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