کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5531995 | 1401825 | 2016 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons](/preview/png/5531995.png)
- FoxO promotes dendrite branching in all classes of Drosophila dendritic arborization (da) neurons.
- FoxO is required for initiating growth of new branches and for maintaining existing branches.
- FoxO is necessary and sufficient for anterograde microtubule polymerization in dendrites.
- FoxO promotes proper larval nociception.
The size and shape of dendrite arbors are defining features of neurons and critical determinants of neuronal function. The molecular mechanisms establishing arborization patterns during development are not well understood, though properly regulated microtubule (MT) dynamics and polarity are essential. We previously found that FoxO regulates axonal MTs, raising the question of whether it also regulates dendritic MTs and morphology. Here we demonstrate that FoxO promotes dendrite branching in all classes of Drosophila dendritic arborization (da) neurons. FoxO is required both for initiating growth of new branches and for maintaining existing branches. To elucidate FoxO function, we characterized MT organization in both foxO null and overexpressing neurons. We find that FoxO directs MT organization and dynamics in dendrites. Moreover, it is both necessary and sufficient for anterograde MT polymerization, which is known to promote dendrite branching. Lastly, FoxO promotes proper larval nociception, indicating a functional consequence of impaired da neuron morphology in foxO mutants. Together, our results indicate that FoxO regulates dendrite structure and function and suggest that FoxO-mediated pathways control MT dynamics and polarity.
Journal: Developmental Biology - Volume 418, Issue 1, 1 October 2016, Pages 40-54