کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5532849 1402082 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autophagosome Maturation and Fusion
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Autophagosome Maturation and Fusion
چکیده انگلیسی

Highlight
- Summary of current knowledge of autophagy maturation and fusion literature

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes.

Graphical Abstract90

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 429, Issue 4, 17 February 2017, Pages 486-496
نویسندگان
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